非小细胞肺癌脑转移放射治疗预后评价及治疗进展

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1、授予单位代码10089学号或申请号20153534中国图书分类号R734.2HebeiMedicalUniversity硕士学位论文专业学位非小细胞肺癌脑转移放射治疗预后评价及治疗进展研究生：杨晨导师：乔学英教授专业：肿瘤学二级学院：第四医院2018年03月目录中文摘要············································································································1英文摘要·····················

2、·······················································································2英文缩写·············································································································3综述非小细胞肺癌脑转移放射治疗预后评价及治疗进展·····························4致谢···········

3、····························································································································32个人简历·············································································································33中文摘要非小细胞肺癌脑转移放射治疗预后评价及治疗进展摘要

4、非小细胞肺癌是最常见的恶性肿瘤之一，近一半的患者在治疗过程中或后会发生脑转移。脑转移严重影响患者的生活质量并缩短生存时间。为了对脑转移患者预后进行预测，很多学者提出了不同的预后评价体系。目前脑转移的治疗方式主要有全脑放疗、立体定向放疗、手术、化疗、靶向治疗等，其中放射治疗仍是最主要治疗方式之一。随着放疗技术和靶向药物的快速发展，很多研究表明此两种治疗模式的联合可提高局控率并改善生存时间，但最佳联合方式尚未有定论。本文就NSCLC脑转移放射治疗的预后评价及治疗进展进行综述。关键词：非小细胞肺癌，脑转移，放射疗法，靶向治疗，预后评价1英

5、文摘要Prognosticindicesandupdateofradiotherapyforpatientswithbrainmetastasisinnon-smallcelllungcancerABSTRACTNon-smallcelllungcancer(NSCLC)isoneofthemostcommonmalignancies.AndabouthalfofthepatientswithNSCLCdevelopbrainmetastasisduringand/oraftertreatment.Brainmetastasesse

6、riouslyaffectthequalityoflifeandshortensurvivaltime.Inordertopredicttheprognosisofpatientswithbrainmetastasesafterradiotherapy,manyscholarshaveproposeddifferentprognosticevaluationsystems.Nowadays,thetreatmentmodalitiesforbrainmetastasesmainlyincludes:wholebrainradioth

7、erapy(WBRT),stereotacticradiotherapy,surgery,chemotherapy,targetedtherapyandevensupportivecare.Radiationtherapyisstilloneofthemostimportanttreatmentmodality.Withtherapiddevelopmentofradiotherapytechniqueandthetargetedtherapies,manystudiesshowedthatthecombinationofthese

8、twotreatmentmodalitiescouldincreasethelocalcontrolofbrainmetastasisandimprovethesurvivaltime,butthebestcombinationhas