单激素受体阳性乳腺癌的临床特点及预后研究

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1、单激素受体阳性乳腺癌的临床特点及预后研究谢文秀，曹悦族，彭钢胜，夏育，张文洛，杨璐［摘要］目的掇讨单橄索受体PU性乳腺統的临体病理及找后特点。方法说取2000年1月一2004年12月就诊的1〜III期乳腮痂568例・H中雎皴素受体(estrogenreceptor.ER)¥阳型乳嫁癌80例和孕激我受^(proResteronereceptor.PR)单阳熨乳腺癌58例(共)38例)•分析两组单激素亞体乳腿純的临床病理恃征及预后舒点.结果PR单阳熨能年龄£50岁以及絶经前燈者比洌显齐高于ER呗阳生组(PV0.05>；ER及PR单阳型乳腺癌的天扁生存期(

2、discasc-frersurvival,DFS),总生“期(oerallsurv.VJ.l,OS)^H无统计学直义(P>0.05)iER单阳墩组的DFS,OS明总优于双阴熨乳廉伽(PV0.05).但PR单尿型组与苴差异无统计•护意义(P>0・05)；PR单阳型组的DFS及OS较双阳型乳腮癌乩拆缩短(PV0.05〉.而ER单阳出组与其料异无统计学盘义(尸>山05)。结论PR单阳中乳多见丁•年轻、绝经前女性，与ER单阳型乳腺癌的生存期差异无统计学.臥义订啾单阳煜乳腺癌的预忘接近「双阴型乳探編、而ER服阳型乳廉轴则更接近于双阳型乳谋癌・［关雀词］乳腺种繼

3、；雌激索受休，孕微水受体［中图分类号］R737.9［文献林志码］B［文章编号］1009-3427(2011)03-0142-03ClinicalandprognosticcharacteristicsofsinglehormonereceptorpositivebreastcancerXIEWen-jriu^CAOYuean,PENGChao-sheng*X1AJing«ZHANGWeirLuu,YANGLu(DepartmentoftheSpecialCareMedicalCenter.NavalGeneralHospital.Beijing100

4、048,China)_Abstract:ObjectiveToanalyzetheclinicalandprognosticcharacteristicsofsinglehormonereceptorpositivebreastcancer.MethodsFivehundredandsixtyeihgtI—111breastcancerpatientsinclude80ER十/TR—subjectsand58ER—/PR+subjectsadmittedtoNavalGeneralHospitalfron^January2000toDecember2

5、004wereenrolledinthisstudy・Theclinicalandprognosticcharacterwerecompared・ResultsER—/PR+tumorswerefoundmorefrequentlyinyounger^premenopausalwomen(P<0.05)・SurvivalanalysesshowednodifferencebetweenER4-/PR—andER—/PR4~tumorintermsofdisease^freeintervalandoverallsurvival(P>0・05)・How

6、ever,whoncomparedwiththedouble-negativt!phenotype,theER+/PR—patientsshowedanassociationwithbetteroutcomebutnosurvivaladvantagewasdetectedincaseofER—/PR+tumors.Whencomparedwiththedouble-positivephcnotype»theER—/'PR+groupshowedworseoutcomewhereasnosuchsurvivaldifferencewasdete

7、ctedinER4-/PR—tumors・ConclusionER—/PR+tumorsarefoundmorefrequentlyinyounger・jiremenopausalwomen♦anditsoutcomeisclosetodouble-negativetumorsiwhereasER-I-/PR—tumorsoutcomeimcloaetodoublepositivetumors.［Keywords］Breastcancer；Estrogenreceptor；Progesteronereceptor单激素受体阳性乳腺癌Jingleho

8、rmonercceptorpositivebreastcancer）指雌激索受体（estrogenrecep