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1、[经典]术前动脉灌注化疗治疗局部晚期宫颈癌疗效分析术前动脉灌注化疗治疗局部晚期宫颈癌疗效分析【摘要】目的观察动脉灌注介入化疗对局部晚期宫颈癌的治疗效果。方法38例Ib2期和12期宫颈癌患者中16例行术前子宫动脉灌注介入化疗,用顺钳80mg/m2,化疗2〜3疗程。每次介入治疗间隔10〜14do化疗后3〜4周行广泛子宫切除术+盆腔淋巴结清扫术。22例直接行广泛子宫切除术+盆腔淋巴结清扫术两种治疗方法。结果16例患者经介入化疗后CR4例,PR10例,总有效率为87.5%o所有患者化疗后
2、均行手术切除。与直接手术患者比较,手术时间和出血量明显减少(P〈0.05,P<0.005),术后病理发现肿瘤深肌浸润明显减少(P<0.05)o结论介入治疗对局部晚期以上宫颈癌有一定的近期疗效,可以提高手术切除率,是宫颈癌综合治疗的有效手段之一。【关键词】宫颈癌;新辅助化疗;动脉栓塞ToEvaluatEffectsofPreoperativeIntroarterialChemotherapyinLocallyAdvancedCervicalCancerSHIShao-quan,YANGGuang-we
3、i,LIUChang-qing,etal.TheFifthAffiliatedHospitalofSunYat-senUniversity,Zhuhai519000,China[Abstract]ObjectiveToobservetheefficacyofIntroarterialChemotherapyinpatientswithLocallyadvaneedstageuterinecervixancer・Methods16patientshadreceivedthepreoperativech
4、emotherapyconsistedof2-3cyclesofintroarterialcisplatin80mg/m2interval10-14days,followedbyradicalhysterectomywithpelviclymphadenectomyand22patientshadreceivedradicalhysterectomywithpelviclymphadenectomyonlyinallthirty-eightcervicalcancerpatien
5、tsstagedasIb2orIIa.ResultsThenumberofCR,PRwere4and10respectivelyin16patientsreceivedthepreoperativeintroarterialchemotherapy.Thetotaltumorregressionratewas87.5%.all16patientsunderwentradicalhysterectomywithpelviclymphadenectomy.Tocomparedoperativeandpa
6、thologicdataafterradicalhysterectomyinthetwogroups,thereweresignificantdifferencesinoperatingtime,estimatedbloodloss(P<0.05,P<0.005).Theratioofcervicaldeepstromalinvasioninintroarterialchemotherapygroupwaslowerthanthoseintheimmediateradicalsurgerygroup
7、.ConclusionTheshort-termeffectivewasobservedinthisstudy.Thepreoperativeintroarterialchemotherapycandecreasethetumorsizeandbenefittofollowingradicalsurgery.Itmightbeagoodtreatmentoptioninpatientswithlocallyadvancedcervicalcancer・[Keywords]Uterinecervixc
8、ancer;Neoadjuvantchemotherapy;Arterialembolism宫颈癌是妇科常见的恶性肿瘤,手术和放疗是主要的治疗手段。近年來,由于化疗药物的迅猛发展,化疗已经成为宫颈癌的重要辅助治疗手段。自从上世纪80年代开始,新辅助化疗逐渐应用于局部晚期宫颈癌,介入化疗作为一种有效的区域性化疗方法,已逐渐应用于宫颈癌治疗中,并取得了较为满意的疗效,使部分患者获得了手术机会。1资料与方法1.1一般资料2007年4月至2009年7月我院收治的Ib2期和Il