玻璃体腔内注射贝伐单抗对增生性糖尿病视网膜病变玻璃体手术的影响

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1、玻璃体腔内注射贝伐单抗对增生性糖尿病视网膜病变玻璃体手术的影响【摘要】目的：评估术前1o，PPV组和IVB组视力都明显提高(82.1%对88.9%)(P<0.01)，两组间并无明显差异。医源性视网膜裂孔发生率PPV组18例，IVB组4例(64.3%对22.2%)(P<0.05)。术中出血PPV组28例，IVB组7例(100%对39%)(P<0.01)，术后出血PPV组9例，IVB组0例(32.1%对0)(P<0.01)。结论：术前注射贝伐单抗可以减少增生性糖尿病视网膜病变玻璃体手术中医源性视网膜裂孔、术中出血和术后出

2、血发生率。【关键词】贝伐单抗;血管内皮细胞生长因子;增生性糖尿病视网膜病变;玻璃体切除手术　INTRODUCTION　　Nonclearingvitreoushaemorrhage,preretinalfibrovascularmembraneandtractionalretinaldetachmentaremajorcausesofseverevisiondecreaseinpatientsyisgenerallyusedtoremovevitreoushaemorrhageandpreretinalfibrovascularmembra

3、nesandreliefofvitreoretinaltraction.IntraoperativebleedingandiatrogenicretinalbreaksainplicationsduringsurgeryofremovingpreretinalfibrovascularmembraneinPDR[2].Intraoperativebleedinginterferesination,detectionofiatrogenicretinalbreaks,performinglasertherapyandleadstotimec

4、onsumingsurgery.Ghostcellglauaandpostoperativebleedingaremainconsequencesofthisplication[3].　　Bevacizumab(Avastin),arebinantmonoclonalantibodyagainstvascularendothelialgroinistration(FDA)forthetreatmentformetastaticcolorectalcancer.Recentreportsontheintravitrealbevacizumab

5、(IVB)injectionshoisefortargetingVEGFimplicatedintraocularneovascularizationseeninagerelatedmaculardegenerationandproliferativediabeticretinopathy(PDR)[4].Ithasbeenrecentlyshoorrhageandinduceinvolutionofretinalneovascularizationandanteriorsegmentneovascularizationentofpro

6、liferativediabeticretinopathy(PDR)andotherretinalvasculardiseases[4,5].Thepurposeofthisstudyistoevaluatetheeffectofintravitrealbevacizumab(IVB)injectionbeforevitrectomyinPDRpatients.　　MATERIALSANDMETHODS　　ParticipantsandGroupingPreoperativeevaluationincludedbloodhypertensi

7、on,bloodglucose,bestcorrectedvisualacuity(BCVA),slitlamp,gonioscopy,ultrasonographyandfundusfluoresceinangiography(FFA).Thesurgicalindicationincludedpreretinalfibrovascularmembraneinvolvingorthreateningthemacula,unclearingvitreoushemorrhageofatleast1month,vitreoushemorrh

8、ageassivepreretinalbleedingcoveringtheposteriorpoleandBCVAof0.12orodialysis,historyofIVBi