尿ngal与妊高症肾损伤的相关分析

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1、尿NGAL与妊高症肾损伤的相关分析［摘要］目的探?尿中性粒细胞明胶酶相关脂质运载蛋白（NGAL）水平与妊娠期高血压肾损伤疾病病情进展的关系。方法选择我院2014年9月〜2016年4月间住院治疗并分娩的妊娠期高血压患者60例为观察组（妊娠期高血压患者27例，轻度子痫前期患者15例，重度子痫前期患者6例，子痫期患者12例）；选择60例妊娠期健康孕妇为对照组。分别检测患者入院24h内和产后72h的尿NGAL、血肌酎（Cr）及血清胱抑素C（Cys-C）水平，分析其与妊娠期高血压肾损伤疾病的严重程度及临床表现的关系。结果入院24h各组尿NGAL、血

2、Cr含量均高于产后72h，Cys-C水平低于产后72h,差异具有统计学意义（P<0.05）；除妊娠期高血压组和轻度子痫前期组，各亚组间尿NGAL、血Cr含量差异均有统计学意义（P〈0.05）；Cys-C含量妊娠期高血压组、轻度子痫前期组以及子痫期组之间差异均存统计学意义（P〈0.05）;尿NGAL与妊娠期高血压肾损伤的严重程度呈正相关。结论检测尿NGAL水平可以早发现、早诊断、早治疗妊娠期高血压肾损害，对于临床决策、母婴健康及治疗子痫相关并发症的发生有重要意义。本文采集自网络，本站发布的论文均是优质论文，供学习和研究使用，文中立场与本网站

3、无关，版权和著作权归原作者所右，如存不愿意被转载的情况，请通知我们删除己转载的信息，如果需要分享，请保留本段说明。［关键词］中性粒细胞明胶酶相关脂质运载蛋白；妊娠；高血压•，肾损伤［中图分类号］R692；R714.2［文献标识码］A［文章编号］2095-0616(2017)07-119-04CorrelationanalysisofurinaryNGALandrenalinjuryinpatientswithpregnancyinducedhypertensionHUANGGuanglianPURongWANGBoqinClinicalL

4、aboratory,DongguanThirdPeople’sHospital,Dongguan523326，China［Abstract］ObjectiveToexploretherelationshipofurinaryneutrophilgelatinaseassociatedlipidcarrierprotein(NGAL)levelandpregnancyinducedhypertensionrenalinjurydiseaseprogression.Methods60casesofpregnancyinducedhyperte

5、nsionhospitalizedanddeliveriedinourhospitalfromSeptember2014toApril2016wereselectedastheobservationgroup(including27casesofpregnancyinducedhypertension,15casesofmildpreeclampsia，6casesofseverepreeclampsia，and12casesofeclampsia).60healthypregnantwomenwereselectedascontrolg

6、roup.ThelevelsofurinaryNGAL,serumcreatinine(Cr)andserumcystatinC(Cys-C)inthepatientswith24hand72hafteradmissionweredetermined.TherelationshipbetweenthelevelsofurinaryNGAL,serumcreatinine(Cr),serumcystatinC(Cys-C)andseverityofhypertensivedisordersinpregnancy,clinicalmanife

7、station.ResultsTheurineNGALandbloodCrlevelsinthe24hwerehigherthanthoseinthepostpartum72h.TheCys—Clevelinthe24hwaslowerthanthatofpostpartum72h.Andthedifferenceswerestatisticallysignificant(P<0.05).ThereweresignificantdifferencesinNGALandCrlevelsinurinebetweenthesubgroup,ex

8、cepthypertensivegroupandmildpreeclampsiagroup(P<0.05).TherewasasignificantdifferenceinCys—Cconte