ngal在狼疮性肾炎肾小管间质中的表达

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1、英文摘要ExpressionofNGALintherenaltissueofpatientsofLNnephropathywithtubulointerstitialdamageABSTRACTobjective：Systemiclupuserythematosus(SLE)isanautoimmunedisordercausedbythemultifactor．AndthekidneyisthemostcommonlyaffectsvitalorgansinSLEdisease．Early,urineabno

2、rmalorkidneydysfu。nctionis25％to50％，andtherenalbiopsyrevealedalmostallSLEpatientshavethevaryingdegreeofkidneydamageandtherenaldamageincreasedthemortalityofSLEpatients．CurrentlyLNistheleadingcauseofsecondaryglomerulardisease．AtpresenceithasconfirmedthatL．Npati

3、entsoftencompanionoftubular-interstitiallesion(TIL)，nLhascloserelationshipwimrenaldamage，andintheearlystageitcanappearsmanypathologicalchangessuchasrenaltubulardegenerationandnecrosisandinterstitialinflammatorycellsinfiltrating．Alongwiththefurtheraggravateof

4、thediseaseitcancauserenaltubularatrophyandinterstitialfibrosis．StudiesshowthattheactiveLNpatientshasthehigherincidenceofimpairmentoftherenaltubulesfuctionthanthetubulointerstitiumpathologicalchange．Renaltubularinterstitialfib．rosis(TIF)isanimportantcharacter

5、isticofrenalsclerosis．Therenalfibrosisisthecommonpathwaysoftheprogressiontoend．stagerenalfailureinmanychronicl(idneydiseases(CKD)．Renaltubularinterstitialfibrosismanifeststherenaltubulesbasementmembranethickened，tubularepithdialcellsshrink，the‘nfiltrationof‘

6、nterstitialinflammatorysmallalarterialwalIntlltratlonotinterstitialandinterstitialarterialwal1thickening，collagenandfibronectinsecretionincreased，renaltubularandinterstitialcapillarylossandextracellularmatrix(ECM)excessiveaccumu．1ation．Recentlyfindingsshowth

7、atneutrophilgelatinase。associatedlipocalin(NGhL)hasplayedanimportantroleinrestrainingtheinterstitialfibrosisinkidneyandthendelayedthedevelopmentofchronickidneydisease．ThisstudyisaimedtoanalysetheexpressionleveloftheNGALinpatientswithlupusnephritisactiverenal

8、1esionsandinactiverenallesions．andtherelations．4英文摘要hipbetweentheexpressionandthepathologicalchange，clinicalmanifestationwasanalyzedtoexplorethesignificanceofNGALintheprogressionofLNnephropathya