不同程度母爱剥夺对成年大鼠学习记忆影响的实验研究

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1、授予单位代码10089学号或申请号13918HebeiMedicalUniversity硕士学位论文在职科学学位不同程度母爱剥夺对成年大鼠学习记忆影响的实验研究作者姓名：葛晶导师：李双成副教授专业：人体解剖与组织胚胎学二级学院：基础医学院2015年03月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下，由本人独立完成。本学位论文研究所获得的研究成果,其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单

2、位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。研究生签名：I‘导师签章级学院领导盖章:2oiJ年J月k日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外,文中不包含其他人已经发表或撰写的研究成果,指导教师对此进行了审定。本论文由本人独立撰写，文责自负。年目录中文摘要····························································

3、·················1英文摘要·············································································3英文缩写·············································································5研究论文不同程度母爱剥夺对成年大鼠学习记忆影响的实验研究前言··············································

4、·······························6材料与方法····································································7结果·············································································9附图······································································

5、·······12附表·············································································14讨论·············································································15结论·············································································18参考文献··

6、·····································································18综述海马持续记忆的预期性与回顾性：时间优先？····················21致谢···················································································44个人简历····················································

7、·························45中文摘要不同程度母爱剥夺对成年大鼠学习记忆影响的实验研究摘要许多研究表明人类生命早期应激(earlylifetimeevents，ELS)是成年后行为学及多种精神疾病的重要风险因素,可诱发严重抑郁症（majordepression）、物质使用障碍(substanceusedisorder)、创伤后应激障碍(posttraumaticstressdisorder)、认知缺陷(cognitivedeficit)、儿童注意缺陷症(childrenattention

8、deficit)及精神分裂症(schizophrenia)等疾病，但是其内在机制我们知之甚少。近来关于其致病机制的研究主要集中在神经内分泌系统，由于道德的约束及方法学的限制，以人为对象的研究还是有限的。为了进一步深入、全面地探讨生命早期应激引起人类精神疾病发病的机制的研究，现在主要采用动物模型。其中，应用于啮齿类动物的母爱剥夺（母婴分离maternalseparation,MS）模型,