呼吸道合胞病毒致毛细支气管炎研究进展

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1、http://www.paper.edu.cnCurrentperspectiveonrespiratorysyncytialviruscaused1bronchiolitisSuMiaoshang，LiChangchongDepartmentofRespiratory,YuyingChildren'sHospitalofWenzhouMedicalCollege，Wenzhou，Zhejiang（325027）E-mail：sumish@163.comAbstractBronchiolitiscausedbyrespiratorysyncytialvirus(RSV)isacommon

2、lowerrespiratorytractinfectiousdiseaseofyoungchildren.Inrecentyears,studiesonthelinkwithbronchiolitisandasthmaarepayedmoreattentionincreasingly,especiallyonthosewithatopy.Thisreviewfocusontheepidemiology,immunopathogenesisanddevelopmentofasthmaafterbronchiolitis,treatmantandpreventionofbronchioli

3、tismaybeinvolved.Keywords:bronchiolitis;asthma;respiratorysyncytialvirus1.IntroductionBronchiolitisisacommonlowerrespiratorytractinfectiousdiseaseofyoungchildren.Clinicalfeaturesincludeexpiratorywheezing,tachypnea,andhypoxiacausedbyobstructionofthesmall[1]airways.Bronchiolitiscausedbyrespiratorys

4、yncytialvirus(RSV)isoftenhappenedintheageof2to5months,Ithasbeenseldomtobediagnosedintheageoflessthan1monthorolderthan[2]2year.Ithappenedfrequentlyinwinterandspringandwiththecharacterofwheezyandasthmaticsuffocation.Inmanyclinicalstudies,allwheezingillnessesinchildrenyoungerthan3yearsofagehavebeend

5、iagnosedasbronchiolitisotherthanasthma.Inthepastyears,RSVbronchiolitisisstrikinglycorrelationwithasthmainthefollowingyearsinyoung[3-4]children.recentstudiesshowthatRSVinfectioninducesmixedtypeTh1/Th2mediatedcytokineresponsivnessduringtheearlystage，earlyexpressionofIFN-γplaytheimmpoetantroleincont

6、rollingthebalanceofTh1/Th2immuneresponsiveness.macrophageinflammatoryprotein1α/1β（MIP-1α/1β）,monocytechemoattractantprotein1(MCP-1)、monocytechemoattractantproteinexpressedandsecreted（RANTES）andchemotacticfactorofeosinophils（Eotaxin）caninduceEOS,lymphocyteandotherimmunecellstogathertowardinflammat

7、ionallocation,theninduceEOS,basophilegranulocyte,mastocytetoreleasemediatorsofinflammation.bymeansof[5]theseeffectionsubstituteTh2mediatedcytokineresponsivness.besides.RecentyearsTregulatorycells(treg)havebecomemoreint