检测血清肿瘤指标在乳腺癌的临床价值

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1、上海交通大学硕士学位论文检测血清肿瘤指标在乳腺癌的临床价值姓名：丁皓姝申请学位级别：硕士专业：外科学（普外）指导教师：全志伟;张生来2008050601级七年制硕士研究生论文（P=0.000），且三项指标联合检测敏感性显著提高，达64.1%。转移时血清CA-125和CA15-3水平与ER呈正相关（PCA-125=0.049，PCA15-3=0.039）。多脏器转移者血清CA15-3、CEA和CA-125浓度明显高于单脏器转移者（P=0.000）。远处转移病例CA15-3和CEA水平与局部复发病例存在统计学差

2、异（PCA15-3=0.001，PCEA=0.022）。结论：血清CA15-3、CEA和CA-125检测因敏感性低而限制其在原发性乳腺癌辅助诊断中临床应用。在乳腺癌随访中，血清CA15-3、CEA和CA-125浓度升高是监测乳腺癌转移的有效指标。乳腺癌转移时血清CA15-3和/或CA-125浓度升高可能提示患者对内分泌治疗更敏感。关键词：乳腺癌癌胚抗原糖类抗原153糖类抗原125转移01级七年制硕士研究生论文CLINICALVALUEOFDETECTINGSERUMTUMORMARKERINBREASTCA

3、NCERABSTRACTObjective:ToinvestigatetherelationshipbetweenserumlevelsofCA15-3,CA-125andCEAandclinicopathologicalparametersandpathogeneticconditionturnover.Methods:FromJanuary2004toDecember2007,atotalof402breastdiseasecaseswithintegrityclinicalinformation,wh

4、ichfromgeneralsurgeryandoncologydepartmentofXinhuaHospitalaffiliatedtoShanghaiJiaotongUniversitySchoolofMedicine,werecollectedandfoundtheclinicaldatabase.TheserumconcentrationofCA15-3,CA-125andCEAweredeterminedbychemiluminescentimmunoassay(CLIA).WilcoxonKr

5、uskalWallisanalysis,crosstableanalysisandspearmancorrelationanalysiswereusedtoinvestigateassociationsbetweenserumconcentrationandclinicalparametersandpathogeneticconditionturnover.Results:TheserumlevelofCEAinbreastcancerpatientswashigherthanitinbenignbreas

6、tdiseasegroup(P=0.003)whilethelevelofCA15-301级七年制硕士研究生论文andCA-125hadnosignificantdifference(P>0.05).TheserumlevelofCA15-3andCEAinstageⅢⅠgroupwashigherthanitinstage/Ⅱgroup(PCA15-3=0.013,PCEA=0.03).ThesensitivityofdetectingCA15-3,CEAandCA-125combinedwassigni

7、ficanthigherthandetectingthemisolated(P=0.000).TheCA15-3levelhadthepositivecorrelationbetweentumorsize,stageandnodalstate(Psize=0.000,Pstage=0.002,PLN=0.002).ThetumorstageandnodalstatewerecorrelatedwiththeserumlevelofCEA(Pstage=0.001,PLN=0.018).ThelevelofC

8、A-125wascorrelatedwiththetumorsizeandstage(Psize=0.006,Pstage=0.014).TheserumconcertrationofCA15-3,CA-125CEAandinmetastaticbreastcancergroupweresignificanthigherthanthoseinnonmetastaticpatients(P=0.000).These