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1、第18卷第4期江苏大学学报(医学版)Vol.18No.42008年7月JournalofJiangsuUniversity(MedicineEdition)Jul.2008血糖波动对2型糖尿病肾病发病的影响薄亚文,成金罗(南京医科大学附属常州市第二人民医院内分泌代谢科,江苏常州213003)[摘要]目的:探讨血糖波动对2型糖尿病患者肾病并发症的影响。方法:采用动态血糖监测系统(CGMS)对68例2型糖尿病患者进行连续24h血糖监测,以24h内平均血糖标准差(SDBG)反映血糖波动;通过测定24h尿蛋白定量(24h2UAE)描述肾病并发症的程度,并行平均动脉压、血脂、糖化血红蛋白(h
2、emoglobinA1c,HbA1c)、体质量指数(bodymassindex)测量。结果:(1)2型糖尿病无肾病并发症、合并早期肾病并发症、合并临床肾病并发症的患者SDBG分别为(1.64±0.45),(1.87±0.43),(2.82±0.81)mmol/L。(2)相关分析显示,相同条件下,经对数变换后的24h2UAE与SDBG的相关系数为0.612,与平均动脉压的相关系数为0.558(P<0.01)。(3)线性回归分析显示,经对数变换后的24h2UAE与SDBG、平均动脉压的β值分别为0.519,0.451。结论:初步认为血糖波动与2型糖尿病肾病并发症的发生发展有相关性。[关
3、键词]动态血糖监测;平均血糖标准差;血糖波动;糖尿病肾病[中图分类号]R587.2[文献标志码]A[文章编号]1671-7783(2008)04-0330-04CorrelationbetweenbloodglucosefluctuationanddiabeticnephropathyBOYa2wen,CHENGJin2luo(DepartmentofEndocrinologyandMetabolism,TheChangzhouSecondPeople′sHospitalAffiliatedtoNJMU,ChangzhouJiangsu213003,China)[Abstract]
4、Objective:Todiscussthecorrelationbetweenbloodglucosefluctuationanddiabeticne2phropathy.Methods:Sixty2eightindividualswithtype2diabetesmellituswereobservedwithcontinuousglucosemonitoringsystem(CGMS)for24hours.Analyzethestandarddeviationofmeanlevelofbloodglu2cosefluctuationwithin24hours(SDBG).To
5、determinethelevelof24h2urinaryalbuminexcretionfordefi2ningdiabeticnephropathy.Meanarterialpressure,bloodfat,hemoglobinA1candbodymassindexweremeasured.Results:(1)TheSDBGwere1.64±0.45,1.87±0.43and2.82±0.81mmol/L,respectivelyinpatientswithnormoalbuminuria,microalbuminuriaandmacroalbuminuria.(2)It
6、wasindicatedbycorre2lationanalysisthatunderthesamecircumstancethecorrelationcoefficientbetween24h2UAEafterlogarith2mictransformationandSDBGwas0.612andthecorrelationcoefficientbetween24h2UAEafterlogarithmictransformationandmeanarterialpressurewas0.558(P<0.01).(3)Itwasindicatedbylinearregression
7、a2nalysisthatthevalueofβbetween24h2UAEafterlogarithmictransformationandSDBGand24h2UAEaf2terlogarithmictransformationandmeanarterialpressurewas0.519and0.451respectively.Conclusion:Itwasinitiallyconsideredthatbloodglucosefluctuationmaybea
