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ID:9141868
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时间:2018-04-19
《多巴胺受体激动剂普拉克索治疗帕金森病非运动症状的疗效观察》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、多巴胺受体激动剂普拉克索治疗帕金森病非运动症状的疗效观察湘西自治州人民医院湖南湘西416000目的探讨多巴胺受体激动剂普拉克索治疗帕金森病非运动症状的临床疗效。方法选取帕金森病非运动症状患者76例,将患者随机分为两组,观察组38例,给予多巴胺受体激动剂普拉兑索治疗,对照组38例,给予左旋多巴和帕罗西汀治疗,比较两组患者治疗前后汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)、简易精神状态检查(MMSE)量表评分及治疗前后帕金森病白主神经症状发生情况。结果两组患者治疗后HAMA量表评分、HAMD量表评分、MMSE量表评分
2、与治疗前比较有显著差异,P<0.05,且观察组变化更加明显,P<0.05;两组治疗后患者各类自主神经症症状较治疗前有改善,其屮观察组尿频尿急、口干、体位性低血压症状的发生率较治疗前明显降低,P<0.05,对照组各项症状变化不明显,P>0.05。结论多巴胺受体激动剂普拉克索能明显缓解帕金森病患者焦虑、抑郁精神状态,改善患者各类自主神经症症状,安全有效,值得推广。【关键词】多巴胺受体激动剂普拉克索帕金森非运动症状【Abstract】objectivetoinvestigatedopamineagonistsp
3、ramipexoleclinicalcurativeeffectforthetreatmentofthemotorsymptomsofParkinson'sdisease.MethodtoselectthemotorsymptomsofParkinson'sdisease,76casesofpatients,patientswererandomlydividedintotwogroups,observationgroup38examples,givingdopamineagonistspramipexoletreatment,c
4、ontrolgroup38cases,levodopaandparoxetinetreatment,comparedtwogroupsbeforeandaftertreatmentinpatientswithHamiltonanxietyscale(HAMA)andHamiltondepressionscale(HAMD),simplementalstateexamination(MMSE)ratingscaleandautonomicnervesymptomoccurrenceofParkinson'sdiseasebefor
5、eandaftertreatment.ResultstwogroupsaftertreatmentinpatientswithHAMAscalescore,HAMDscalescore,MMSEscalescore,therewasasignificantdifferencecomparedwithbeforetreatment,P<0.05,andtheobservationgroupchangeismoreobvious,P<0.05;Twogroupsaftertreatmentinpatientswithva
6、rioustypesofindependentneurosissymptomsimprovedcomparedwithbeforetreatment,theobservationgroupoffrequenturinationurgency,drymouth,theincidenceoforthostatichypotensionsymptomssignificantlylowerthanbeforetreatment,P<0.05,thecontrolgroup,thesymptomisnotobvious(P>0
7、.05).Conclusiondopamineagonistspramipexolecanobviouslyrelieveanxiety,depression,mentalstatusinpatientswithParkinson'sdiseasetoimprovepatientswithallkindsofindependentneurosissymptoms,safeandeffective,isworthpromoting.【Keywords】dopamineagonistsPramipexoleParkinson'sth
8、anmotorsymptoms帕金森病是一种神经系统变性疾病,好发于中老年人群,主要临床特征有肌强直、静止性震颤、姿势反射障碍及运动迟缓。近年来,随着医学水平的不断发展,对帕金森病的认识也在不断提高,帕金森患者的一些非运动症状如自主神经症状、精神症状、感觉障碍、
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