shh的激活对永久性脑缺血大鼠细胞骨架蛋白α-tubulin、map-2表达的影响-(5353)

《shh的激活对永久性脑缺血大鼠细胞骨架蛋白α-tubulin、map-2表达的影响-(5353)》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、AbstractTheActivationoftheSHHPathwayAffectstheCytoskeletalProteinQ-tubulinandⅣ【AP．2inStrokeRatModelPostgradute：MiaomiaoChenTutor：ProfHongyingBaiDepartmentofNeurology,TheSecondClinicalCollegeofZhengzhouUniversity．Zhengzhou，Henan450014，ChinaBackgroundand0bjectiveNow,

2、lifeexpectancyhasbeenrisen，thespeedoftheaccelerationoftheagingisincreasing,thechangesindietaftertheimprovementoflivingstandardsisobvious，thelackofphysicalexerciseisremarkable，allthesef．actorspromotestheincidenceandtheprevalencerateofischemiccerebrovascdardiseasetor

3、iseyearbyyear．Itisseriouslyharmfulandevenlife—threateningtopeoplewhosufferfromthecerebrovasculardisease．Soexceptforexploringthemechanismofstroke，howtofindthestrategytoreducetheincidenceofthediseaseandcureitisalsoacriticaltasknow．ThecerebralischemiclesioniSdividedin

4、totheischemiccoreandtheischemicpenumbra,thedamageontheneuronsoftheischemicpenumbraisreversible,SOitishelpfultorepairtheimpairedneuronsfromimprovingtheirplasticity．Thedynamicchangesofthelevelofcytoskeletalproteinshasacloserelationtotheneurons’survivalandfunctionalst

5、ates，furthermore,thecytoskdetalproteinCanacceleratetheprocessoftheneurons’growthandincreasetheirplasticity,SOit’Sverysignificativetoexplorehowtoincreasetheabilityofcytoskeletalproteinonneuron’Sremairment，whichcouldimprovepatient’Somcome．Sonichedgehog(Shh)signalingp

6、athwayisoneofthemainhedgehogsignalingpathways．RecentstudiesshowthatShhsignalingpathwayiscloselyIV一垒垒!咝!一——————_———————_———————————————————————————_—_——————●———————_—————————————一一一relatedtotheremodelingofthecytoskeletalprotein．TheactivationofShhsignalingpathwaycall

7、notonlyincreasetheexpressionlevelofcytoskeletalprotein，butimprovetheirstability．Themicrotubule(MTs)isoneofthemaincomponentsinthecytoskeleton，伐．tubulinisoneoftheimportantcomponentswhichconsistMTs．Inthenervoussystem，theMTsisnotonlythemarkerproteinduringtheneurocytes’

8、growth，butisthepivotalproteinintheprocessofneurons’repairmentontheirs仃uc【ureandfunctionsaftertheneuronsweredamaged．MAP-2isalsooneofthemaincytoske