莫西沙星治疗慢性阻塞性肺疾病急性加重期的临床对照研究

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1、授予单位代码10089学号或申请号13226•；儿v多H并d科大坌HebeiMedicalUniversity硕士学位论文在职科学学位莫西沙星治疗慢性阻塞性肺疾病急性加重期的临床对照研究学位申请人：张秀义导师：阎锡新教授专业：内科学二级学院：第二医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组〉的指导下，由本人独立完成。本学位论文研究所获得的研究成果,其知识产权归河北医科大学所有-河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等

2、知识产权均归河北医科大学所有。否则,承担相应法律责任。研究生签名：朱彦少导师签级学院领导盖章:fy年〈月-河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外,文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：W义导师签章！x年〈月了目录中文摘要·············································································1英文摘要·················

3、····························································3英文缩写·············································································5研究论文莫西沙星治疗慢性阻塞性肺疾病急性加重期的临床对照研究前言·············································································6资料与方法·····························

4、·······································7结果·············································································13附表·············································································16讨论·············································································23结论··

5、···········································································26参考文献·······································································26综述慢性阻塞性肺病急性加重期近年治疗研究进展····················29致谢···················································································37个人

6、简历·············································································38中文摘要莫西沙星治疗慢性阻塞性肺疾病急性加重期的临床对照研究摘要目的：对慢性阻塞性肺疾病急性加重期(AcuteEχacerbationofChronicObstructivePulmonaryDisease,AECOPD)的患者分别采用莫西沙星、左氧氟沙星、阿莫西林克拉维酸钾来经验性治疗，通过对照观察3种药物在慢性阻塞性肺疾病急性加重期的疗效，以期选择出比较好的经验性用药。方法：本研究全部病例90例均为201

7、3年10月～2015年2月间河北承德市中心医院呼吸科住院患者。采用简单随机单盲法，根据患者的住院顺序，随机分为三组，莫西沙星组，左氧氟沙星组，阿莫西林/克拉维酸钾组，每组患者各30例。莫西沙星组:莫西沙星注射液400mg静脉输入，滴注时间维持90min，1次/d，疗程为7d；左氧氟沙星组：左氧氟沙星氯化钠注射液400mg静脉滴注，1次/d，滴注时间维持90min，疗程7d；阿莫西林克拉维酸钾组：注射用阿莫西林钠克拉维酸钾1.2g溶于100ml氯化钠注射液中，静脉滴注30分钟，3次/d，疗程7d。三组患者均同时进行吸氧、扩张支气管、雾化吸入激素、及营养